Shyni Varghese


Professor of Biomedical Engineering, Mechanical Engineering & Materials Science and Orthopaedics

Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Appointments and Affiliations

  • Professor of Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Ph.D. National Chemical Laboratory (India), 2002

Research Interests

Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study
  • ME 221L: Structure and Properties of Solids

In the News

Representative Publications

  • Shih, Y-RV; Liu, M; Kwon, SK; Iida, M; Gong, Y; Sangaj, N; Varghese, S, Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss., Science Advances, vol 5 no. 8 (2019) [10.1126/sciadv.aax1387] [abs].
  • Zeng, Y; Hoque, J; Varghese, S, Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair., Acta Biomater, vol 93 (2019), pp. 152-168 [10.1016/j.actbio.2019.01.060] [abs].
  • Serrano, R; Aung, A; Yeh, Y-T; Varghese, S; Lasheras, JC; Del Álamo, JC, Three-Dimensional Monolayer Stress Microscopy., Biophysical Journal, vol 117 no. 1 (2019), pp. 111-128 [10.1016/j.bpj.2019.03.041] [abs].
  • Shih, YV; Varghese, S, Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials., Biomaterials, vol 198 (2019), pp. 107-121 [10.1016/j.biomaterials.2018.06.005] [abs].
  • Katrekar, D; Chen, G; Meluzzi, D; Ganesh, A; Worlikar, A; Shih, Y-R; Varghese, S; Mali, P, In vivo RNA editing of point mutations via RNA-guided adenosine deaminases., Nat Methods, vol 16 no. 3 (2019), pp. 239-242 [10.1038/s41592-019-0323-0] [abs].