Louis E DeFrate


Professor in Orthopaedic Surgery

Appointments and Affiliations

  • Professor in Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Frank H. Bassett III, M. D. Associate Professor
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study

In the News

Representative Publications

  • Englander, ZA; Wittstein, JR; Goode, AP; Garrett, WE; DeFrate, LE, Reconsidering Reciprocal Length Patterns of the Anteromedial and Posterolateral Bundles of the Anterior Cruciate Ligament During In Vivo Gait., Am J Sports Med (2020) [10.1177/0363546520924168] [abs].
  • Goode, AP; Schwartz, TA; Kraus, VB; Huebner, JL; George, SZ; Cleveland, RJ; Gracely, R; Jimenez, M; DeFrate, LE; Chen, J; Golightly, YM; Jordan, JM, Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project., J Orthop Res, vol 38 no. 5 (2020), pp. 1027-1037 [10.1002/jor.24534] [abs].
  • Englander, ZA; Garrett, WE; Spritzer, CE; DeFrate, LE, In vivo attachment site to attachment site length and strain of the ACL and its bundles during the full gait cycle measured by MRI and high-speed biplanar radiography., J Biomech, vol 98 (2020) [10.1016/j.jbiomech.2019.109443] [abs].
  • Englander, ZA; Baldwin, EL; Smith, WAR; Garrett, WE; Spritzer, CE; DeFrate, LE, In Vivo Anterior Cruciate Ligament Deformation During a Single-Legged Jump Measured by Magnetic Resonance Imaging and High-Speed Biplanar Radiography., Am J Sports Med, vol 47 no. 13 (2019), pp. 3166-3172 [10.1177/0363546519876074] [abs].
  • Ruprecht, JC; Waanders, TD; Rowland, CR; Nishimuta, JF; Glass, KA; Stencel, J; DeFrate, LE; Guilak, F; Weinberg, JB; McNulty, AL, Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects., Scientific Reports, vol 9 no. 1 (2019) [10.1038/s41598-019-44855-3] [abs].