Louis E DeFrate


Professor in Orthopaedic Surgery

Appointments and Affiliations

  • Professor in Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Frank H. Bassett III, M. D. Associate Professor
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study

In the News

Representative Publications

  • Cutcliffe, HC; DeFrate, LE, Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties., Methods Mol Biol, vol 2230 (2021), pp. 199-215 [10.1007/978-1-0716-1028-2_12] [abs].
  • Englander, ZA; Spritzer, CE; DeFrate, LE, In vivo attachment site to attachment site length and strain of the ACL and its bundles during the full gait cycle measured by MRI and high-speed biplanar radiography: Response., J Biomech, vol 109 (2020) [10.1016/j.jbiomech.2020.109918] [abs].
  • Cutcliffe, HC; Davis, KM; Spritzer, CE; DeFrate, L, The Characteristic Recovery Time as a Novel, Noninvasive Metric for Assessing In Vivo Cartilage Mechanical Function., Ann Biomed Eng (2020) [10.1007/s10439-020-02558-1] [abs].
  • Englander, ZA; Wittstein, JR; Goode, AP; Garrett, WE; DeFrate, LE, Reconsidering Reciprocal Length Patterns of the Anteromedial and Posterolateral Bundles of the Anterior Cruciate Ligament During In Vivo Gait., Am J Sports Med, vol 48 no. 8 (2020), pp. 1893-1899 [10.1177/0363546520924168] [abs].
  • Goode, AP; Schwartz, TA; Kraus, VB; Huebner, JL; George, SZ; Cleveland, RJ; Gracely, R; Jimenez, M; DeFrate, LE; Chen, J; Golightly, YM; Jordan, JM, Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project., Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, vol 38 no. 5 (2020), pp. 1027-1037 [10.1002/jor.24534] [abs].