Louis E DeFrate


Frank H. Bassett III, M. D. Associate Professor

Appointments and Affiliations

  • Frank H. Bassett III, M. D. Associate Professor
  • Associate Professor in Orthopaedic Surgery
  • Associate Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 791: Graduate Independent Study
  • BME 792: Continuation of Graduate Independent Study

In the News

Representative Publications

  • Englander, ZA; Martin, JT; Ganapathy, PK; Garrett, WE; DeFrate, LE, Automatic registration of MRI-based joint models to high-speed biplanar radiographs for precise quantification of in vivo anterior cruciate ligament deformation during gait., Journal of Biomechanics, vol 81 (2018), pp. 36-44 [10.1016/j.jbiomech.2018.09.010] [abs].
  • Taylor, KA; Collins, AT; Heckelman, LN; Kim, SY; Utturkar, GM; Spritzer, CE; Garrett, WE; DeFrate, LE, Activities of daily living influence tibial cartilage T1rho relaxation times., Journal of Biomechanics (2018) [10.1016/j.jbiomech.2018.10.029] [abs].
  • Sutter, EG; Liu, B; Utturkar, GM; Widmyer, MR; Spritzer, CE; Cutcliffe, HC; Englander, ZA; Goode, AP; Garrett, WE; DeFrate, LE, Effects of Anterior Cruciate Ligament Deficiency on Tibiofemoral Cartilage Thickness and Strains in Response to Hopping., The American Journal of Sports Medicine (2018) [10.1177/0363546518802225] [abs].
  • Collins, AT; Kulvaranon, ML; Cutcliffe, HC; Utturkar, GM; Smith, WAR; Spritzer, CE; Guilak, F; DeFrate, LE, Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI., Arthritis Research & Therapy, vol 20 no. 1 (2018) [10.1186/s13075-018-1727-4] [abs].
  • Collins, AT; Hatcher, CC; Kim, SY; Ziemian, SN; Spritzer, CE; Guilak, F; DeFrate, LE; McNulty, AL, Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times., Annals of Biomedical Engineering (2018) [10.1007/s10439-018-02143-7] [abs].