Louis E DeFrate


Professor in Orthopaedic Surgery

Appointments and Affiliations

  • Professor in Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Frank H. Bassett III, M. D. Associate Professor
  • Associate Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Crook, BS; Collins, AT; Lad, NK; Spritzer, CE; Wittstein, JR; DeFrate, LE, Effect of walking on in vivo tibiofemoral cartilage strain in ACL-deficient versus intact knees., J Biomech, vol 116 (2021) [10.1016/j.jbiomech.2020.110210] [abs].
  • Kim-Wang, SY; Scribani, MB; Whiteside, MB; DeFrate, LE; Lassiter, TE; Wittstein, JR, Distribution of Bone Contusion Patterns in Acute Noncontact Anterior Cruciate Ligament-Torn Knees., Am J Sports Med, vol 49 no. 2 (2021), pp. 404-409 [10.1177/0363546520981569] [abs].
  • Collins, AT; Hu, G; Newman, H; Reinsvold, MH; Goldsmith, MR; Twomey-Kozak, JN; Leddy, HA; Sharma, D; Shen, L; DeFrate, LE; Karner, CM, Obesity alters the collagen organization and mechanical properties of murine cartilage., Scientific Reports, vol 11 no. 1 (2021) [10.1038/s41598-020-80599-1] [abs].
  • Cutcliffe, HC; DeFrate, LE, Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties., Methods Mol Biol, vol 2230 (2021), pp. 199-215 [10.1007/978-1-0716-1028-2_12] [abs].
  • Andress, B; Kim, JH; Cutcliffe, HC; Amendola, A; Goode, AP; Varghese, S; DeFrate, LE; McNulty, AL, Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding., Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society (2020) [10.1002/jor.24954] [abs].