Louis E DeFrate


Professor in Orthopaedic Surgery

Appointments and Affiliations

  • Professor in Orthopaedic Surgery
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Biomedical Engineering
  • Affiliate of the Regeneration Next Initiative

Contact Information


  • Sc.D. Massachusetts Institute of Technology, 2005

Awards, Honors, and Distinctions

  • Kappa Delta Young Investigator Award. American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society. 2016

Courses Taught

  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)

In the News

Representative Publications

  • Heckelman, LN; Wesorick, BR; DeFrate, LE; Lee, RH, Diabetes is associated with a lower minimum moment of inertia among older women: An analysis of 3D reconstructions of clinical CT scans., J Biomech, vol 128 (2021) [10.1016/j.jbiomech.2021.110707] [abs].
  • Coppock, JA; Danyluk, ST; Englander, ZA; Spritzer, CE; Goode, AP; DeFrate, LE, Increasing BMI increases lumbar intervertebral disc deformation following a treadmill walking stress test., J Biomech, vol 121 (2021) [10.1016/j.jbiomech.2021.110392] [abs].
  • Englander, ZA; Lau, BC; Wittstein, JR; Goode, AP; DeFrate, LE, Patellar Tendon Orientation and Strain Are Predictors of ACL Strain In Vivo During a Single-Leg Jump., Orthopaedic Journal of Sports Medicine, vol 9 no. 3 (2021) [10.1177/2325967121991054] [abs].
  • Crook, BS; Collins, AT; Lad, NK; Spritzer, CE; Wittstein, JR; DeFrate, LE, Effect of walking on in vivo tibiofemoral cartilage strain in ACL-deficient versus intact knees., J Biomech, vol 116 (2021) [10.1016/j.jbiomech.2020.110210] [abs].
  • Kim-Wang, SY; Scribani, MB; Whiteside, MB; DeFrate, LE; Lassiter, TE; Wittstein, JR, Distribution of Bone Contusion Patterns in Acute Noncontact Anterior Cruciate Ligament-Torn Knees., Am J Sports Med, vol 49 no. 2 (2021), pp. 404-409 [10.1177/0363546520981569] [abs].