Seminar: Constructing 3D Heterogenous Hydrogels on an Electromicrofluidic Platform

Nov 2

Friday, November 2, 2018

3:00 pm - 4:30 pm
Hudson Hall 207

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Presenter

Dr. Shih-Kang Fan | National Taiwan University

Dr. Shih-Kang 'Scott' Fan

Manufacturing of three-dimensional (3D) architectures through assembly of (1) prepolymer hydrogel droplets with suspended cells/particles/molecules and (2) crosslinked building blocks with reorganized embedded objects is demonstrated on an electromicrofluidic platform. The complex and heterogeneous 3D architectures are in great demand in various applications, including in the construction of artificial tissues that recapitulate physiological functions by imitating biological structures and in the production of novel metamaterials with properties atypical or nonexistent in nature. 3D hydrogel building blocks with reorganized cells or particles are formed and assembled on the electromicrofluidic platform adopting electrowetting and dielectrophoresis.

We demonstrate the manipulations of varied objects (a) in multiple phases such as prepolymer liquid hydrogel droplets and crosslinked hydrogels, (b) on a wide range of scales from micrometer cells or particles to millimeter assembled hydrogel architectures, (c) with diverse properties such as conductive and dielectric prepolymer droplets that are photo, chemically, or thermally crosslinkable, and (d) in adjustable geometries including discrete droplets and continuous liquid columns. 3D hydrogel architectures, composed of varied particles or cells reorganized in programmable patterns and biomimetic hydrogels of designed properties and in adjustable geometries, are obtained. The electromicrofluidic platform is general and alternative to manipulate cells and hydrogel for reconfigurable 3D architectures.

Shih-Kang Scott Fan is Distinguished Professor of the Mechanical Engineering Department and Researcher of the Center for Biotechnology in National Taiwan University (NTU), Taiwan. He received his B.S. from National Central University, Taiwan in 1996 and the M.S. and Ph.D. degrees from University of California, Los Angeles (UCLA) in 2001 and 2003, respectively. In 2004, Dr. Fan became Assistant Professor at National Chiao Tung University, Taiwan, and rose to Associate Professor in the Institute of Nanotechnology and the Department of Material Sciences before he moved to NTU in 2012.

Dr. Fan's research interests include electrowetting, electromicrofluidics, in vitro diagnosis, and advanced manufacturing. He is the recipient of several awards, including the “Ta-You Wu Memorial Award” from National Science Council (2011), the “Research Award for Junior Research Investigators” from Academia Sinica (2012), the “Young Scholar’s Creativity Award” from Foundation for the Advancement of Outstanding Scholarship (2014), the “TBF Chair in Biotechnology” from Taiwan Bio-Development Foundation (2014), and “Outstanding Research Award” from Ministry of Science and Technology (2017). He was elected Fellow of Royal Society of Chemistry in 2016. He also served in professional societies and conferences, including serving as General Chair of the International Conference on Optofluidics 2015 and the International Meeting on Electrowetting 2016.

Hosted by Dr. Tony Huang

Contact

Dzwonczyk, Laura
919-681-3132
laura.dzwonczyk@duke.edu