MEMS Seminar: Multiphysics and Multiscale Modeling of Cardiac Dynamics

Mar 8

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Wednesday, March 8, 2017 - 1:30pm to 2:30pm


Professor Boyce Griffith

The heart is a coupled electro-fluid-mechanical system. The contractions of the cardiac muscle are stimulated and coordinated by the electrophysiology of the heart; these contractions in turn affect the electrical function of the heart by altering the macroscopic conductivity of the tissue and by influencing stretch-activated transmembrane ion channels. In this talk, I will present an overview of our work to develop computer models of cardiac mechanics, fluid dynamics, and electrophysiology, as well as applications of these models and methods to cardiac fluid-structure and electro-mechanical interaction. I will particularly focus on work on simulating the performance of natural and prosthetic heart valves, and the validation of these models by comparison to in vitro experiments. To develop these models, we are also advancing broadly applicable simulation technology for modeling biological fluid-structure interaction, and I will describe several applications of these methods, including to neuromuscular control of swimming and esophageal transport.

Boyce Griffith is an Assistant Professor of Mathematics and Adjunct Assistant Professor of Biomedical Engineering at The University of North Carolina at Chapel Hill. His training is in applied mathematics, computer science, and physiological modeling, and his primary research interests are to use computer modeling and simulation to study biological systems, especially cardiovascular physiology and pathophysiology, and to develop mathematical and computational infrastructure that enables such models. Lunch will be served from 1-1:30 pm.