Stefan Zauscher

Stefan Zauscher

Sternberg Family Professor of Mechanical Engineering & Materials Science

My research lies at the intersection of surface and colloid science, polymer materials engineering, and biointerface science, with four central areas of focus: 1. Fabrication, manipulation and characterization of stimulus-responsive biomolecular and bio-inspired polymeric nanostructures on surfaces; 2. Nanotechnology of soft-wet materials and hybrid biological/non-biological microdevices; 3. Receptor-ligand interactions relevant to the diagnostics of infectious diseases; 4. Friction of soft-wet materials, specifically the role of glycoproteins on friction in diarthroidal joints. These four broad lines of inquiry deal with fundamental behaviors of soft-wet materials on surfaces and interfaces. The design and fabrication of these interfaces using "smart" polymeric and biomolecular nanostructures, and the characterization of the resulting structures, are critically important for the development of biomolecular sensors and devices and for bioinspired materials. Key approaches and tools I use in my research are: bottom-up organization on the molecular scale, through self-assembly, in-situ polymerization, and manipulation of intermolecular interactions; topdown fabrication, through scanning probe nanolithography; stimulus-responsive polymers; molecular recognition; and new approaches to sensing and manipulation. This research supports Duke's Pratt School of Engineering strategic initiative to expand research in soft-wet Materials Science.

Appointments and Affiliations

  • Sternberg Family Professor of Mechanical Engineering & Materials Science
  • Professor in the Department of Mechanical Engineering and Materials Science
  • Professor in the Department of Chemistry
  • Faculty Network Member of The Energy Initiative

Contact Information


  • Ph.D. University of Wisconsin at Madison, 1999
  • M.S. Oregon State University, 1992

Research Interests

Nano-mechanical and nano-tribological characterization (elasticity, friction, adhesion) of materials including organic thin films; self-assembled monolayers, polymeric gels, and cellulosics; Fabrication of polymeric nanostructures by scanning probe lithography; Colloidal probe and atomic force microscopy; Single molecule force spectroscopy applied to ligand-receptor binding; Biomolecular nano- and micro sensors


Nanomaterial manufacturing and characterization
Polymer and Protein Engineering
Sensing and sensor systems

Awards, Honors, and Distinctions

  • ICCES Young Investigator Award. International Center for Computational Engineering Sciences. 2008
  • NSF Early CAREER Award. National Science Foundation. 2008
  • Oak Ridge Associated Universities Faculty Enhancement Award. Oak Ridge Associated Universities. 2008
  • Young Investigator Award. American Academy of Nanomedicine. 2008
  • Bronze Award for Scientific Achievement. 26th Army Science Conference, U.S. Army Research. 2008

Courses Taught

  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 529: Theoretical and Applied Polymer Science (GE, BB)
  • BME 791: Graduate Independent Study
  • EGR 391: Projects in Engineering
  • EGR 393: Research Projects in Engineering
  • ME 492: Special Projects in Mechanical Engineering
  • ME 514: Theoretical and Applied Polymer Science (GE, BB)
  • ME 555: Advanced Topics in Mechanical Engineering
  • ME 758S: Curricular Practical Training
  • ME 759: Special Readings in Mechanical Engineering
  • MENG 550: Master of Engineering Internship/Project
  • MENG 551: Master of Engineering internship/Project Assessment

Representative Publications

  • Gu, R; Lamas, J; Rastogi, SK; Li, X; Brittain, W; Zauscher, S, Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates., Colloids and Surfaces B: Biointerfaces, vol 135 (2015), pp. 126-132 [abs].
  • Lee, W; Leddy, HA; Chen, Y; Lee, SH; Zelenski, NA; McNulty, AL; Wu, J; Beicker, KN; Coles, J; Zauscher, S; Grandl, J; Sachs, F; Guilak, F; Liedtke, WB, Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage., Proceedings of the National Academy of Sciences of USA, vol 111 no. 47 (2014), pp. E5114-E5122 [abs].
  • Parlak, Z; Tu, Q; Zauscher, S, Liquid contact resonance AFM: analytical models, experiments, and limitations., Nanotechnology, vol 25 no. 44 (2014) [abs].
  • Hardy, GJ; Wong, GC; Nayak, R; Anasti, K; Hirtz, M; Shapter, JG; Alam, SM; Zauscher, S, HIV-1 antibodies and vaccine antigen selectively interact with lipid domains., Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, vol 1838 no. 10 (2014), pp. 2662-2669 [abs].
  • Tang, L; Tjong, V; Li, N; Yingling, YG; Chilkoti, A; Zauscher, S, Enzymatic polymerization of high molecular weight DNA amphiphiles that self-assemble into star-like micelles, Advanced Materials, vol 26 no. 19 (2014), pp. 3050-3054 [10.1002/adma.201306049] [abs].
Professional Society Service:
  • American Chemical Society (ACS):
    • - Division of Polymer Chemistry (POLY)
    • - Division of Polymeric Materials: Science and Engineering (PMSE)
    • - Division of Colloid and Surface Chemistry (COLL)
    American Vacuum Society (AVS)
    • - Biomaterial Interfaces Division (BID)
    Materials Research Society (MRS)