Lori A. Setton

Image of Lori A. Setton

William Bevan Professor of Biomedical Engineering

Research in Setton's laboratory is focused on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus. Work in the Laboratory is focused on engineering and evaluating materials for tissue regeneration and drug delivery. Studies combining engineering and biology are also used to determine the role of mechanical factors to promote and control healing of cartilaginous tissues. Research in the Laboratory is funded by The National Institutes of Health, The Coulter Foundation and The North Carolina Biotechnology Center.

Appointments and Affiliations
  • William Bevan Professor of Biomedical Engineering
  • Bass Fellow
  • Professor of Biomedical Engineering
  • Faculty Network Member of the Duke Institute for Brain Sciences
Contact Information:

  • Ph.D. Columbia University, 1993
  • B.S.E. Princeton University, 1984

Curriculum Vitae

Tissue Repair, Engineering
Biological Materials

Awards, Honors, and Distinctions:

  • Van C. Mow Medal. American Society of Mechanical Engineers. 2007
  • Fellows. American Institute for Medical and Biological Engineering. 2005

Courses Taught:
  • BME 394: Projects in Biomedical Engineering (GE)
  • BME 493: Projects in Biomedical Engineering (GE)
  • BME 494: Projects in Biomedical Engineering (GE)
  • BME 530: Introduction to Tissue Biomechanics (GE, BB)
  • BME 791: Graduate Independent Study
  • BME 792: Graduate Independent Study

Representative Publications: (More Publications)
    • Mwangi, TK; Bowles, RD; Tainter, DM; Bell, RD; Kaplan, DL; Setton, LA, Synthesis and characterization of silk fibroin microparticles for intra-articular drug delivery., International Journal of Pharmaceutics, vol 485 no. 1-2 (2015), pp. 7-14 [10.1016/j.ijpharm.2015.02.059] [abs].
    • Hwang, PY; Jing, L; Michael, KW; Richardson, WJ; Chen, J; Setton, LA, N-Cadherin-Mediated Signaling Regulates Cell Phenotype for Nucleus Pulposus Cells of the Intervertebral Disc., Cellular and Molecular Bioengineering, vol 8 no. 1 (2015), pp. 51-62 [10.1007/s12195-014-0373-4] [abs].
    • Kimmerling, KA; Furman, BD; Mangiapani, DS; Moverman, MA; Sinclair, SM; Huebner, JL; Chilkoti, A; Kraus, VB; Setton, LA; Guilak, F; Olson, SA, Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis., European cells & materials, vol 29 (2015), pp. 124-139 [abs].
    • Karikari, IO; Gilchrist, CL; Jing, L; Alcorta, DA; Chen, J; Richardson, WJ; Gabr, MA; Bell, RD; Kelley, MJ; Bagley, CA; Setton, LA, Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines., Journal of neurosurgery. Spine, vol 21 no. 3 (2014), pp. 386-393 [10.3171/2014.4.spine13262] [abs].
    • Jeong, CG; Francisco, AT; Niu, Z; Mancino, RL; Craig, SL; Setton, LA, Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis., Acta Biomaterialia, vol 10 no. 8 (2014), pp. 3421-3430 [10.1016/j.actbio.2014.05.012] [abs].