Molecular ultrasound intervention using microbubbles
Cheri X. Deng, Ph.D.
Department of Biomedical Engineering
University of Michigan
Ultrasound has a long history for medical applications with notable advantages including its non-invasiveness and superior safety profile. The robust interactions of ultrasound with gaseous microbubbles offer unique opportunities to develop novel strategies for an array of biomedical applications. In particular, techniques of ultrasound excitation and actuation of functionalized microbubbles that target to specific cellular receptors provide new and intriguing cellular access for biomedical ultrasound. In this presentation, I will discuss two approaches that exploit such interactions. The first is sonoporation, i.e., ultrasound induced transient disruption of cell membrane, which has the potential as an advantageous technique for non-viral gene transfection. The second is acoustic tweezing cytometry, a new technique we recently developed for applying spatiotemporally controlled subcellular forces to probe cellular mechanical properties and elicit desirable mechanoresponses with implications in areas such as stem cell differentiation.
Event co-sponsored by the Duke Medical Imaging Training Program
I received my doctorate in Mechanical Engineering from Yale University in 1995, and was a research staff member in the Biomedical Engineering Directorate, Riverside Research Institutes in New York City from 1995-2002. I was an assistant professor in the Department of Biomedical Engineering, Case Western Reserve University from 2002-2006, and an associate professor of Biomedical Engineering at the University of Michigan since 2007-2013. I am currently a professor of Biomedical Engineering at the University of Michigan.
The goal of my research is to develop new and improved strategies utilizing ultrasound technologies for the diagnosis and treatment of human diseases. Our research focuses on the mechanistic understanding of ultrasound interaction with biological systems and to employ the ensuing insights in development of new strategies. Our research projects funded by the U.S. National Institutes of Health (NIH) and other agencies include ultrasound mediated drug and gene delivery for cancer treatment and gene therapy, high intensity focused ultrasound ablation of cardiac arrhythmias, as well as quantitative ultrasound imaging for pancreatic cancer detection and treatment monitoring. Our work has been published in a variety of professional journals including PNAS, Ultrasound in Medicine and Biology, Radiology, Annals of Biomedical Engineering, Journal of Controlled Release, Journal of Bacteriology, Biophysical Journal, Gastrointestinal Endoscopy, Applied and Environmental Microbiology, Applied Physics Letter, and Journals of the Acoustic Society of America.
I teach both undergraduate and graduate BME courses, including Biotransport, quantitative cell biology, and special topic courses such as Cell and Microenvironment Engineering with Micro-technology and Ultrasound.Date: Wednesday, Oct 1, 2014
Time: 11:30 am - 1:30 pm
Where: 125 Hudson Hall
Contact: Prof. Pei Zhong