"all-optical electrophysiology"

Sep 8

Thursday, September 8, 2016

4:30 pm - 5:30 pm
Fitzpatrick Center Schiciano Auditorium Side B


Professor Emilia Entcheva Department of Biomedical Engineering George Washington University

Professor Emilia EntchevaDepartment of Biomedical EngineeringGeorge Washington UniversityAbstract:Optical targeting (stimulation or recording) allows distributed parallel access to thousands and even millions of cells and locations at the same time, and within the tissue setting; optical targeting is high-throughput by nature. In this talk, I will discuss and demonstrate the combination of optogenetic stimulation with optical imaging of electrical activity in cardiomyocytes, i.e. the realization of "all-optical electrophysiology" in a high-throughput manner (HTS). Examples will include demonstration of cardiac "wave steering" by light and the use of a new fully-automated all-optical HTS platform (OptoDyCE) for drug screening using patient-derived cardiomyocytes (iPS-CMs). Bio:Dr. Emilia Entcheva is a Professor of Biomedical Engineering at George Washington University; she recently moved her laboratory to Washington DC, after 15 years as faculty at Stony Brook University. She directs the Cardiac Optogenetics and Optical Imaging Laboratory. Her research group has contributed to the development of new tools for optical mapping of cardiac excitation, computational modeling of cardiac electrophysiology, as well as innovative techniques to engineering cardiac tissue and its functional characterization using lab-on-a-chip platforms.


King, Pamela